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Castlemans
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CLINICAL TRIALS

Clinical trials are research studies in which new treatments - drugs, diagnostics, procedures, vaccines, and other therapies - are tested in people to see if they are safe and effective.

The purpose of a clinical trial is to determine whether a new treatment option is safe, effective and a better alternative to current standard care methods. Volunteer participation by men and women of all races and ethnicities is essential, if researchers are to find the best treatment regimens.

Results of clinical trials that prove a new treatment to be safe and effective are reviewed by the U.S. Food and Drug Administration, which determines if and when it can be marketed for use by all patients with that particular disease.

The U.S. National Institutes of Health, through its National Library of Medicine, has developed Clinical Trials to provide patients, family members and members of the public current information about clinical research studies. Before searching, you may want to learn more about clinical trials. 

Clinical Trials:

Castlemans Disease

A Phase I Study of Multiple Intraveneous Administrations of a Chimeric Antibody Against Interlukin-6 in Subjects with B-Cell Non-Hodgkin's Lymphoma, Multiple Myeloma, or Castleman's Disease. - OPEN (3/2008)

Virotherapy and Natural History Study of KSHV-Associated Multicentric Castleman's Disease - open(1/06)

Suramin in Treating Patients With Refractory or Relapsed Multiple Myeloma or Castleman's Disease - closed
 
CD20 Trials

Rituximab Plus CAMPATH in Patient with Relapsed/Refractory Low-Grade or Follicular, CD20-Positive, B-Cell NHL  - open (06/05)

Campath-1H Plus Rituximab for CD52- and CD20- Positive Refractory or Relapsed Chronic Lymphoid Disorders  - open (01/05)

Chemotherapy and Peripheral Stem Cell Transplantation With or Without Monoclonol Antibody Therapy in Treating Patients With Non-Hodgkin's Lymphoma  - open (09/03)
 
Chronic Fatigue Syndrome  

Crohn's Disease  

Epstein-Barr Virus  

Hemangiomas

Direct Injection of Alcohol for the Treatment of Spinal Tumors   - closed


Hodgkin's Disease

Combination Chemotherapy in Treating Patients With Hodgkin's Disease or Non-Hodgkin's Lymphoma That Has Not Responded to Previous Treatment   - closed

Peripheral Stem Cell Transplantation With Specially Treated Stem Cells in Treating Patients With Non-Hodgkin's Lymphoma or Hodgkin's Disease   - closed

Chemotherapy and Radiation Therapy Plus Bone Marrow or Peripheral Stem Cell Transplantation in Treating Patients With Relapsed or Refractory T-cell Lymphoma, Hodgkin's Disease, or Non-Hodgkin's Lymphoma  -  closed

Peripheral Stem Cell Transplantation Following Radiation Therapy in Treating Patients With Hodgkin's Disease or Non-Hodgkin's Lymphoma   -  closed

Interleukin-12 in Treating Patients With Previously Treated Non-Hodgkin's Lymphoma or Hodgkin's Disease   -  closed

Treatment for Chronic Pain in Patients With Advanced Cancer   -  closed
 
Kaposi's Sarcoma

Nicotine Skin Patch in Treating Patients With Kaposi's Sarcoma  - open (2/06)

Infrared Thermography in Finding Skin Lesions in Patients With Kaposi's Sarcoma  - open (1/06)

BAY 43-9006 (Sorafenib) to Treat Patients with Kaposi's Sarcoma  - open (1/06)

Topical Halofuginone Hydrobromide in Treating Patients With HIV-Related Kaposi's Sarcoma  - open (2/06)

Assessment of Blood Vessel Density in Kaposi's Sarcoma Lesions  - open (2/06) 

Celecoxib in Managing Pain, Weight Loss, and Weakness in Patients With Advanced Cancer  - open (10/05

Clinical, Laboratory and Epidemiologic Pilot Studies of Individuals at High Risk for Viral-Associated Cancers  - open (10/05)

Flavopiridol in Treating Patients With Metastatic or Unresectable Refractory Solid Tumors or Hematologic Malignancies  - open (10/05)

Bevacizumab to Treat Kaposi's Sarcoma in HIV-Positive and HIV-Negative Patients  - open (10/05)

Specimen Collections from Patients with HIV Infection, KSHV Infection, Viral-Related Pre-malignant Lesions and Cancer  - open (9/05)

Study of Transfusion-Transmitted Infections  - open (8/05)

Valproic Acid in Treating Patients With Kaposi’s Sarcoma  - open (8/05) 

Imatinib Mesylate in Treating Patients With HIV-Related Kaposi's  - open (6/05) 

Effects of Potent Antiretroviral Therapy on Kaposi's Sarcoma  - open (5/05)

Valganciclovir in Treating Patients With Classic Non-HIV-Associated Kaposi's Sarcoma  - open (5/05)
 
Lupus Disease  

Lymphoma

Monoclonal Antibody Therapy Plus Sargramostim and Interleukin-11 in Treating Patients With Relapsed or Refractory Non-Hodgkin's Lymphoma - open (5/04)

Combination Chemotherapy With or Without Monoclonal Antibody Therapy in Treating Patients With Newly Diagnosed Non-Hodgkin's Lymphoma - open (4/05)

Biological Therapy Following Chemotherapy in Treating Patients With Relapsed or Refractory Non-Hodgkin's Lymphoma  - open (9/04)

Antibody Therapy in Treating Patients With Refractory or Relapsed Non-Hodgkin's Lymphoma or Chronic Lymphocytic Leukemia  - closed
 
Mastocytosis

Therapy of Hypereosinophilic Syndrome, Polycythemia Vera, Atypical CML or CMML With PDGF-R Fusion Genes, or Mastocytosis With Gleevec - open (2/06)

A Study of Oral AMN107 in Adults with Chronic Myelogenous Leukemia (CML) or other Blood Related Cancers- open (1/06)

Dasatinib as Therapy for Myeloproliferative Disorders (MPDs) - open (10/05)

Phase II PKC412 in Aggressive Systemic Mastocytosis and Mast Cell Leukemia  - open (10/05)

Study of Mast Cell Precursors  - open (10/05)

Stem Cell Transplantation to Treat Systemic Mastocytosis  - open (10/05)

Cause and Natural Course of Pediatric-Onset Mastocytosis  - open (9/05) - open (9/05)

Imatinib Mesylate in Patients With Various Types of Malignancies Involving Activated Tyrosine Kinase Enzymes - open (9/05)

17-AAG to Treat Systemic Mastocytosis - open (8/05)

Study of Factors Regulating Mast Cell Proliferation  - open (7/05)

The Characterization of CD34+ Derived Mast Cell Precursors Mobilized by Administration of Granulocyte Colony Stimulating Factor - open (1/05)

Stem Cell Transplantation to Treat Systemic Mastocytosis - open (10/04)

Determination of Cytokine Production Patterns in the Skin of Patients with Systemic Mastocytosis and Atopic Dermatitis Using the Suction Blister Technique - closed

Culture and Characteristics of Mastocytosis Mast Cells   - closed


Multiple Myeloma

A Phase I Study of Multiple Intraveneous Administrations of a Chimeric Antibody Against Interlukin-6 in Subjects with B-Cell Non-Hodgkin's Lymphoma, Multiple Myeloma, or Castleman's Disease. - OPEN (3/2008)

Combination Chemotherapy in Treating Patients With Stage II or Stage III Multiple Myeloma  - open (9/00)

Phase III Randomized Study of Dexamethasone With or Without Bcl-2 Antisense Oligonucleotide G3139 in Patients With Relapsed or Refractory Multiple Myeloma   - closed

Phase II Study of Arsenic Trioxide in Patients With Multiple Myeloma   - closed

Phase II Study of Arsenic Trioxide and Dexamethasone in Patients With Recurrent or Refractory Stage II or III Multiple Myeloma   - closed

Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Patients With Multiple Myeloma   - closed

Comparison of Antibody Therapies in Treating Patients With Graft- Versus-Host Disease That Does Not Respond to Steroid Therapy   - closed

Melphalan and Filgrastim to Stimulate Peripheral Stem Cells in Patients With Multiple Myeloma   - closed

Chemoprevention Therapy in Treating Patients at High Risk of Developing Multiple Myeloma   - closed


Other Related Clinical Trial Sites

Rare Diseases Clinical Research Database

CenterWatch Clinical Trials Listing Service

ACT! - About Clinical Trials

ClinicalTrials.Com

Clinical Research Investigators Registry