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The New England Journal of Medicine -- September 21, 1995 -- Vol. 333, No. 12
Castleman's Disease
A 31-year-old woman who had had painless, right-sided cervical adenopathy for three months was given antibiotics, but the adenopathy persisted. She had no systemic symptoms and no other palpable lymph nodes, and the remainder of her physical examination was unremarkable. The results of all laboratory studies were normal. At surgery the node was 3 cm in diameter, tannish yellow, and rubbery. Histologic examination revealed numerous germinal centers pierced by capillaries emanating from a hypervascular pericortex and cuffed by small lymphocytes arranged in a concentric onionskin pattern (hematoxylin and eosin, x925). These morphologic features are characteristic of Castleman's disease.
Because of the benign nature of the condition, the patient received no further therapy. Ten years after the node appeared, the patient is well and has had no recurrence of lymphadenopathy.
Joshua Z. Sickel, M.D.
University of Rochester Medical Center
Rochester, NY 14642
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DISCLAIMER:
CASTLEMAN's DISEASE HOMEPAGE is provided for educational purposes only. Consult your own physician regarding the applicability of any opinions or recommendations with respect to your symptoms or medical condition.
* CASTLEMAN's DISEASE HOMEPAGE is intended as a reference for health care professionals. The authors and editors have used sources believed to be reliable in their efforts to provide information that is complete and generally in accord with the standards accepted at the time of publication.
Medical knowledge changes rapidly. In view of the possibility of human error or changes in medical science, neither the authors, the editors, St. Vincent Hospital, nor any other party who has been involved in the preparation or publication of this work warrants that the information contained herein is in every respect accurate or complete, and they are not responsible for any errors or omissions or for the results obtained from the use of such information. Readers are encouraged to confirm the information contained herein with other sources.
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