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ICDO
International
Castlemans
Disease
Organization

European Journal of Pediatrics

ISSN: 0340-6199 (printed version)
ISSN: 1432-1076 (electronic version)

Table of Contents

Abstract Volume 158 Issue 8 (1999) pp 631-637

immunology/allergology: Pediatric Castleman disease: report of seven cases and review of the literature

N. Parez (2), B. Bader-Meunier (2), C. C. Roy (1), J. P. Dommergues (2)

(1) Département de Pédiatrie, Hôpital Sainte Justine, Montréal, Canada
(2) Service de Pédiatrie, CHU Bicêtre, 78, rue du Général Leclerc, F-94275 Le Kremlin Bicêtre, France Tel.: +33-1-45 21 32 54, Fax: +33-1-45 21 33 43

Received: 14 November 1997 / Accepted in revised form: 9 September 1998

Abstract Castleman disease is a distinct lymphoproliferative disorder of unknown origin. Seven new cases in children are reported here and 76 cases from the paediatric literature are reviewed. The disease has been reported in 46 females and 37 males, their age ranging from 2 months to 17 years. The disease was localized in 72 cases and multicentric in 11 cases. The hyalinovascular type was more frequently encountered (54%) than the plasma cell type (24%). Laboratory abnormalities were more often associated with the plasma cell type and were mainly represented by anaemia and hypergammaglobulinaemia. Treatment of the localized tumour consisted of surgical excision, whereas treatment of the multicentric form was medical, comprising prednisone and other immunosuppressor drugs. The disease in the paediatric population seems to have a more favourable course than in adults.

Conclusion The paediatric features of the disease suggest that Castleman disease in this population could represent an earlier form of the pathology or even suggest a benign lymphoproliferative disorder.

Key words Castleman disease · Lymphoproliferative disorder

DISCLAIMER:

CASTLEMAN's DISEASE HOMEPAGE is provided for educational purposes only. Consult your own physician regarding the applicability of any opinions or recommendations with respect to your symptoms or medical condition.

* CASTLEMAN's DISEASE HOMEPAGE is intended as a reference for health care professionals. The authors and editors have used sources believed to be reliable in their efforts to provide information that is complete and generally in accord with the standards accepted at the time of publication.

Medical knowledge changes rapidly. In view of the possibility of human error or changes in medical science, neither the authors, the editors, St. Vincent Hospital, nor any other party who has been involved in the preparation or publication of this work warrants that the information contained herein is in every respect accurate or complete, and they are not responsible for any errors or omissions or for the results obtained from the use of such information. Readers are encouraged to confirm the information contained herein with other sources.