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Castleman Disease
- Castleman Disease is a rare B-cell lymphoproliferation disorder
- Castleman Disease occurs in two forms: the more common Localized Castleman Disease often presents as an asymptomatic mediastinal mass, wheras Multicentric Castleman Disease usually presents as a multisystem illness with sidespread lymphadenopathy.
- The diagnosis of Castleman Disease rests upon both the characteristic lymph node histology and the exclusion of other disorders.
- The pathogenesis of Castleman Disease appears to involve dysregulation of IL-6.
- Localized Castleman Disease usually is cured by surgical removal of the mediastinal mass. Multicentric Castleman Disease has a poor prognosis, but may respond to prednisone, chemotherapy or surgical removal of affected nodes and spleen.
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DISCLAIMER:
CASTLEMAN's DISEASE HOMEPAGE is provided for educational purposes only. Consult your own physician regarding the applicability of any opinions or recommendations with respect to your symptoms or medical condition.
* CASTLEMAN's DISEASE HOMEPAGE is intended as a reference for health care professionals. The authors and editors have used sources believed to be reliable in their efforts to provide information that is complete and generally in accord with the standards accepted at the time of publication.
Medical knowledge changes rapidly. In view of the possibility of human error or changes in medical science, neither the authors, the editors, St. Vincent Hospital, nor any other party who has been involved in the preparation or publication of this work warrants that the information contained herein is in every respect accurate or complete, and they are not responsible for any errors or omissions or for the results obtained from the use of such information. Readers are encouraged to confirm the information contained herein with other sources.
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