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ICDO
International
Castlemans
Disease
Organization

Castleman's Disease, surgical treatment. Presentation of two cases

ABSTRACT

Castleman's disease or giant lymph node hyperplasia is frequently located to the chest, but it can also affects the neck, retroperitoneum, pelvis and the mesentery. There are two histologic types: the hyaline-vascular, and the plasma cell type. We present two cases. Case 1: A 46 years old woman with 15 years long diabetes treated with oral hypoglycemic agents. She began her disease with cough, general malaise, weight loss and cervical adenopathies. The chest X-ray showed a wide mediastinum. The surgical finding was a mass encircling the superior caval vein. Histopathological report was lymph node hyperplasia of the hyaline-vascular variant. Case 2: A 42 years old man who worked into chromium and silver mines for a year. He began his disease with mild to moderate dysnea, pain in the left hemithorax, and general malaise. On the chest X-ray there was an opacity in the left parahiliar region. After the surgical intervention the histopathological report revealed Castleman's disease of the hyaline-vascular type. It is important to keep in mind this disease, for which surgical resection is advised, and to follow it up in the long-term due to its malignant potential.

Key words: Castleman's disease, mediastinal enlargement, hyaline-vascular type, plasma cell type.


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CASTLEMAN's DISEASE HOMEPAGE is provided for educational purposes only. Consult your own physician regarding the applicability of any opinions or recommendations with respect to your symptoms or medical condition.

* CASTLEMAN's DISEASE HOMEPAGE is intended as a reference for health care professionals. The authors and editors have used sources believed to be reliable in their efforts to provide information that is complete and generally in accord with the standards accepted at the time of publication.

Medical knowledge changes rapidly. In view of the possibility of human error or changes in medical science, neither the authors, the editors, St. Vincent Hospital, nor any other party who has been involved in the preparation or publication of this work warrants that the information contained herein is in every respect accurate or complete, and they are not responsible for any errors or omissions or for the results obtained from the use of such information. Readers are encouraged to confirm the information contained herein with other sources.