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ICDO
International
Castlemans
Disease
Organization

Hodgkin's and Castleman's disease in a patient with systemic mastocytosis.

Saletti P, Ghielmini M, Scali G, Pedrinis E, Gueneau M, Cavalli F

Department of Oncology, Ospedale S. Giovanni, Bellinzona, Switzerland.

Systemic mastocytosis is a rare condition characterized clinically by the local consequences of vasoactive peptides released from infiltrating mast cells in the reticuloendothelial tissues. Mast cells originate from the pluripotent bone marrow stem cells; it is therefore not surprising that myeloproliferative and myelodysplastic disorders commonly coexist or terminate the clinical phase of mastocytosis. We report here, to our knowledge, the first case of Hodgkin's and Castleman's disease occurring in a patient with co-existent systemic mastocytosis, which remained unchanged after combination chemotherapy for Hodgkin's disease.

Ann Hematol 1999 Feb;78(2):97-100


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